Foldit is an online puzzle videogame developed by the University of Washington’s Center for Game Science in collaboration with the university’s Department of Biochemistry. First released in 2008 for most computer operating systems, Foldit asks its players to manipulate the structure of actual proteins using a wide variety of the game’s own tools and built-in simulations. Subject to much interest and praise since its release, Foldit is revolutionary in that it hopes its players’ puzzle-solving skills and efforts lead to real-life progress in scientific research and development.